Evaluation of antioxidant activity and chemical prospecting of metabolites produced by StreptomyceshygroscopicusS75-5

Background Streptomyces hygroscopicusis a species that produces a variety of antibiotics belonging to different classes. It hás a distinct structure and possesses certain biological properties, such as antimicrobial and antitumor [1]. According to a study by Rong and Huang (2012) [2] more than 650 kinds of bioactive substances have been produced by Streptomyces hygroscopicus and species related to it. Members of this clade are still one of the main means of screening new substances. The aim of this study was to investigate the antioxidant activity and chemical profile of metabolites of Streptomyces hygroscopicus S75-5 obtained by fermentation in liquid and solid media. The antioxidant activity evaluation was conducted using the DPPH method [3] and chemical prospecting following the methodology described by Harborne [4]. The results showed that the extracts of fermentation in the liquid medium presented the highest percentage of antioxidant activity. Chemical prospecting also made it possible to determine the presence of phenolic compounds in the ethyl acetate extract of the metabolic liquid by fermentation in a liquid medium.